Aromatic heterocyclic derivatives as enzyme inhibitors

Details Aromatic heterocyclic derivatives as enzyme inhibitors Aromatic heterocyclic derivatives as enzyme inhibitors

1995-06-07

1997-08-19

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514274, 514349, 544309, 544319, 546194, 546206, 546292, A61K 31445, A61K 31505, C07D21364, C07D23332, C07D23340

Patent

active

056589301

ABSTRACT:
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.

REFERENCES:
patent: 4399065 (1983-08-01), Bajusz
patent: 4433152 (1984-02-01), Muramatsu
patent: 5371072 (1994-12-01), Webb et al.
patent: 5424334 (1995-06-01), Abood
patent: 5492895 (1996-02-01), Vlasuk et al.
Coughlin, P. et al Proc. Natl. Acad. Sci. USA, 1993, 90(20), 9417-21. See Abstract.
Aldrich Chemical Company, Inc. Catalog (1995) p. 283.
Bachem California Catalog (1993-1994) p. 121.
Bachem Bioscience Catalog (1995) p. 721.
Williams et al., "1-(((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2 .2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine (L-368,889): An Orally Bioavailable, Non-Peptide Oxytocin Antagonist with Potential Utility for Managing Preterm Labor," J. Med. Chem. 37:565-571 (1994).
Damewood et al., "Nonpeptidic Inhibitors of Human Leukoycyte Elastase. 2. Design, Synthesis, and in vitro Activity of a Series of 3-Amino-6-arylopyridine-2-one Trifluoromethyl Ketones," J. Med. Chem. 37:3303-3312 (1994).
Skiles et al., "Elastase Inhibitors Containing Conbformationally Restricted Lactams as P.sub.3 -P.sub.2 Dipeptide Replacements," Bioorg. Med. Chem. Lett. 3(4):773-779 (1993).

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