Aromatic derivative and preparation method thereof

Details Aromatic derivative and preparation method thereof Aromatic derivative and preparation method thereof

1990-05-29

1991-02-05

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 45, 560 56, 560 73, 560 85, 560100, 560221, 562455, 562457, 562466, 562490, 564172, 568632, 568633, 568659, 568660, 568808, C07C27900

Patent

active

049906500

ABSTRACT:
1. An aromatic derivative having the formula (I) or the salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 independently represent a hydrogen atom, hydroxyl, a halogen atom, or OR.sup.3 wherein R.sup.3 is C.sub.1 -C.sub.10 alkyl; A-B represents a hydrocarbon moiety having 1 to 10 carbon atoms and containing at least one double bond or a sulfur- or oxygen-containing hydrocarbon moiety having 1 to 10 carbon atoms; n is an integer of 2 to 4; X represents a group ##STR2## and Y represents a hydrogen atom; alkyl having 1 to 5 carbon atoms which may be substituted with aryl; alkenyl having 2 to 5 carbon atoms which may be substituted with aryl or aryl substituted with at least one C.sub.1 -C.sub.5 alkoxy; aryl which may be substituted with at least one carboxy or C.sub.1 -C.sub.5 alkoxycarbonyl or C.sub.1 -C.sub.5 alkoxy; provided that, when R.sup.1 and R.sup.2 are both hydrogen, the moiety --A--B--(CH.sub.2).sub.n --X--Y does not represent ##STR3## wherein n=2 to 4 and R.sup.4 is hydrogen or C.sub.1 -C.sub.5 alkyl.

REFERENCES:
patent: 3943257 (1976-03-01), Anderson et al.
patent: 4243682 (1981-01-01), Goudie et al.
Chemical Abstracts vol. 102, 1985, No. 203756y Teijin Ltd.
Biochemical and Biophysical Research Communications pp. 832-836, vol. 140, No. 3, 1986.
J. Med. Chem. 1987, vol. 30, No. 3, pp. 574-580, Summers et al.

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