Aromatic composition consisting of HLA molecules

Details Aromatic composition consisting of HLA molecules Aromatic composition consisting of HLA molecules

2006-09-19

2006-09-19

Cole, Monique T. (Department: 1743)

Perfume compositions

Perfume compositions

Reexamination Certificate

active

07109158

ABSTRACT:
The invention relates to novel aromatic compositions consisting of HLA molecules, which two different potential perfume carriers are assigned. The invention aims at developing novel aromatic compositions consisting of HLA molecules based on the selection of alleles of genes which are relevant from an olfactory viewpoint and subsequent processing thereof. According to the invention, the aromatic compositions are produced by selecting one allele amongst known class I HLA alleles, which differs in at least one characteristic from other alleles of HLA class I molecules and which is present in less than 5% of individuals of the world population; the protein that is coded for by the selected allele undergoes assembly in the presence of β2-microglobulin (β2m); the formed HLA class I molecules are purified with the bonded peptides and fragmented with the protease, and the odor-active substances resulting from fragmentation are added as individual components or as a mixture to a cosmetic preparation.

REFERENCES:
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Milinski et al. “Evidence for MHC-correlated perfume preferences in humans.” Behavoiral Ecology, vol. 12 No. 2: 140-149, 2001 (http://beheco.oupjournals.org/cgi/content/abstract/12/2/140).
McDonald, Adamashvili; Soluble HLA: a review of the Literature; 1998; 129:258986.
Sommerville et al.; Volatile Indentity Signals in Human Axillary Sweat: the Possible Influence of MHC Class I Genes; 1996; 124:114831.
Zavazava et al.; Regulation of Soluble MHC Class I Molecules; 1996; 124:114826.
Zavazava et al.; Soluble MHC Class I Molecules in Human Body Fluids; 1995; 122:53522.
Eggert, Ferstl and Muller-Ruchholtz; MHC and Olfactory Communication in Humans; 2000; 133:71714.
Wobst et al.; Molecular Forms of Soluble HLA in Body Fluids: Potential Determinants of Body Odor Cues; 1999; 131:241667.

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