Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1977-06-01
1989-06-06
Reamer, James H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
549441, 562456, 562457, 562458, 514563, C07C10154, A61K 31195
Patent
active
RE0329444
ABSTRACT:
Novel aromatic carboxylic amides of the general formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, R.sub.3 and R.sub.4 are hydrogen atoms or together form another chemical bond, each X is a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxy group containing 1-4 carbon atoms, and n is an integer of 1-3 with the proviso that when [Xs] X's are alkyl or alkoxy groups, they may be connected together to form a ring, as well as pharmaceutically acceptable salts thereof.
These compounds possess a strong antiallergenic action and are thus useful for treatment of asthma, hay fever, [anticaria] urticaria and atopic dermatitis.
The above aromatic carboxylic amides can be prepared by reacting a reactive functional derivative of the general formula: ##STR2## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, X and n have the same meanings given above, with an aminobenzoic acid of the formula: ##STR3## and, if desired, converting the resulting amide into the corresponding salts.
REFERENCES:
patent: 3043868 (1962-07-01), Krimmel
patent: 3488737 (1970-01-01), Gordon
patent: 3636694 (1972-01-01), Yonan
Nossier et al. J. Chem. U.A.R., vol. 72, #1, pp. 57-68 (1969).
Kamarkar et al., J. Ind. Chem. Soc., vol. 30, pp. 689-694 (1953).
Seka et al, Monatsh, 53-54, pp. 471-478 (1929).
Nossier et al, J. Chem. U.A.R., pp. 379-390 (1970).
Ajisawa Yukiyoshi
Harita Kozaburo
Iizuka Kinji
Kamijo Tetsuhide
Kinoshita Yukihiko
Kissei Yakuhin Kogyo Kabushiki
Reamer James H.
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