Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1998-09-04
1999-11-02
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514562, 514567, 514570, 549 66, 560 12, 560 16, 560 17, 560 43, 562429, 562431, 562457, 562 64, 564 99, C07C40500, A01K 31557
Patent
active
059771739
ABSTRACT:
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, and Z are defined below. This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof.
The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders and glaucoma. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders and glaucoma using theses compounds or the compositions containing them.
REFERENCES:
patent: 3776938 (1973-12-01), Bergstrom et al.
patent: 3966792 (1976-06-01), Hayashi et al.
patent: 4004020 (1977-01-01), Skuballa et al.
patent: 4011262 (1977-03-01), Hess
patent: 4024179 (1977-05-01), Bindra et al.
patent: 4051238 (1977-09-01), Sokolowski
patent: 4073934 (1978-02-01), Skuballa et al.
patent: 4128720 (1978-12-01), Hayashi et al.
patent: 4154950 (1979-05-01), Nelson
patent: 4206151 (1980-06-01), Grudzinskas
patent: 4621100 (1986-11-01), Lund et al.
patent: 5166178 (1992-11-01), Ueno et al.
patent: 5212324 (1993-05-01), Ueno
patent: 5296504 (1994-03-01), Stjernschantz et al.
patent: 5302617 (1994-04-01), Ueno
patent: 5321128 (1994-06-01), Stjernschantz et al.
patent: 5332730 (1994-07-01), Chan
patent: 5409911 (1995-04-01), Tyler et al.
patent: 5422368 (1995-06-01), Stjernschantz
patent: 5422369 (1995-06-01), Stjernschantz
patent: 5426115 (1995-06-01), Ueno et al.
patent: 5578618 (1996-11-01), Stjernschantz
patent: 5587391 (1996-12-01), Burk
patent: 5627208 (1997-05-01), Stjernschantz et al.
patent: 5665773 (1997-09-01), Klimko et al.
patent: 5688819 (1997-11-01), Woodward et al.
patent: 5703108 (1997-12-01), Cameron et al.
patent: 5834498 (1998-11-01), Burk
Liljebris, C., Selen, G., Resul, B., Stjernschantz, J., and Hacksell, U., "Dervatives of 17-Phenyl-18, 19, 20-trinorprostaglandin F.sub.2.alpha. Isoppropyl Ester: Potential Antiglaucoma Agents", Journal of Medicinal Chemistry, vol. 38, No.2, (1995).
Bundy, G. L., and Lincoln, F. H., "Synthesis of 17-Phenyl-18, 19, 20-Trinoprostaglandins I. The PG.sub.1 Series", Prostaglandins, vol. 9, No. 1, (Jan. 1975).
Amburgey, Jr. Jack S.
Dai Haiyan George
De Biswanath
deLong Mitchell Anthony
Wang Yili
Gerstl Robert
Kellerman James C.
McMahon Mary Pat
Roof Carl J.
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