Aromatic basic-tailed vasopressin antagonists

Details Aromatic basic-tailed vasopressin antagonists Aromatic basic-tailed vasopressin antagonists

1985-03-20

1986-11-25

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514807, 530315, A61K 3734, C07K 716

Patent

active

046249435

ABSTRACT:
Certain new vasopressin-like peptides which have structures characterized by having a bisaminoalkylbenzene present in the vasopressin tail at the 7- or 8-position retain vasopressin antagonist activity. A species of the invention is [1-.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-8-1',4'-bis(aminomethyl)benzene-9-de sglycinamide]-vasopressin.

REFERENCES:
patent: 4367225 (1983-01-01), Manning et al.
patent: 4399125 (1983-08-01), Manning et al.
patent: 4491577 (1985-01-01), Manning et al.
M. Manning et al., Nature, 308 652 (1984).

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