Aromatic amino-alcohol derivatives having anti-diabetic and anti

Details Aromatic amino-alcohol derivatives having anti-diabetic and anti Aromatic amino-alcohol derivatives having anti-diabetic and anti

1995-06-07

1997-06-03

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514651, 560 42, 564349, C07C27934, A61K 31135

Patent

active

056355343

ABSTRACT:
Compounds of formula (I): ##STR1## (wherein: R.sup.0 is hydrogen, methyl or hydroxymethyl; R.sup.1 is substituted alkyl; R.sup.2 and R.sup.3 are each hydrogen, halogen, hydroxy, alkoxy, carboxy, alkoxycarbonyl, alkyl, nitro, haloalkyl, or substituted alkyl; X is oxygen or sulfur; and Ar optionally substituted phenyl or naphthyl); and pharmaceutically acceptable salts thereof have a variety of valuable pharmaceutical activities, including anti-diabetic and anti-obesity activities; in addition, they are capable of treating or preventing hyperlipemia and hyperglycemia and, by inhibiting the action of aldose reductase, they can also be effective in the treatment and prevention of complications of diabetes.

REFERENCES:
patent: 3976783 (1976-08-01), Cox
patent: 5480910 (1996-01-01), Hollowag

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