Aromatic amine derivatives

Details Aromatic amine derivatives Aromatic amine derivatives

1993-09-09

1996-04-16

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514539, 514567, 514603, 514620, 514654, 514655, 558422, 560 37, 562442, 564 86, 564164, 564378, 564387, A61K 31135, C07C21103

Patent

active

055083064

ABSTRACT:
This invention relates to novel aromatic amine compounds having the structure: ##STR1## where each W, Z.sup.1 and Z.sup.2 is independently H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, OH, F, Cl, Br, I, NO.sub.2, CN, SO.sub.2 NHR.sup.3, NR.sup.4.sub.2, CONR.sup.3.sub.2, COR.sup.5 ; where each R.sup.1 and R.sup.2 is independently H, C.sub.1 -C.sub.6 straight or branched chain alkyl or phenyl; where each X and Y is independently CH.sub.2, NR.sup.4, S, S.dbd.O, SO.sub.2 ; where n is 0, 1 or 2; where each p and q is independently 1 or 2; where R.sup.3 is H, C.sub.1 -C.sub.6 straight or branched chain alkyl or phenyl; where R.sup.4 is H, C.sub.1 -C.sub.6 straight or branched chain alkyl or COR.sup.3 ; and where R.sup.5 is H, C.sub.1 -C.sub.6 straight or branched chain alkyl or phenyl, C.sub.1 -C.sub.6 straight or branched chain alkoxy or OH.
In addition the invention includes using such compounds for the treatment of benign prostatic hyperplasia, lowering intraocular pressure and inhibiting cholesterol synthesis.

REFERENCES:
patent: 5137901 (1992-08-01), Junge et al.
patent: 5180746 (1993-01-01), Goto et al.
patent: 5194450 (1993-03-01), McDermed et al.
patent: 5403847 (1995-04-01), Gluchowski et al.
Sam, J. Pharm. Sci., vol. 56, No. 10 (1967) pp. 1344-1347.
Schlicker, E., et al., "Increased Affinity and Preference of Halogenated Derivatives of BE 2254 for alpha.sub.1 -Adrenoceptors Demonstrated by Functional and Binding Experiments," Journal of Cardiovascular Pharmacology (1984), vol. 6, pp. 1238-1244.
Engel, G. et al., "[.sup.125 Iodo] BE 2254, a New Radioligand for alpha.sub.1 -Adrenoceptors," Journal of Cardiovascular Pharmacology (1982), vol. 4, pp. S25-S29.

Affiliated with

Also associated with

Rating

Aromatic amine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aromatic amine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aromatic amine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-325507