Aromatic amidine derivatives and salts thereof

Details Aromatic amidine derivatives and salts thereof Aromatic amidine derivatives and salts thereof

1998-08-07

1999-10-05

Chang, Ceila

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

558406, C07C25552, C07D20709

Patent

active

059626950

ABSTRACT:
An anticoagulant agent which comprises, as an active ingredient, an aromatic amidine derivative represented by the following general formula (1) or a salt thereof: ##STR1## wherein the group represented by ##STR2## is a group selected from indolyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, naphthyl, tetrahydronaphthyl and indanyl; X is a single bond, an oxygen atom, a sulfur atom or a carbonyl group; and Y is a saturated or unsaturated 5- or 6-membered heterocyclic moiety or cyclic hydrocarbon moiety optionally having a substituent group, an amino group optionally having a substituent group or an aminoalkyl group optionally having a substituent group.
The inventive compound has a high anticoagulant capacity based on its excellent FXa inhibition activity.

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Balzarini et al, "Inhibitory Activity of Diarylamidine Derivatives . . . ", CA 99:169063 (1983).

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