Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-06
1996-11-19
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514367, 514373, 514375, 514379, 514393, 514394, 514395, 514408, 514423, 514424, 514428, 514429, 548148, 548165, 548178, 548179, 548180, 548207, 548209, 548217, 548221, 548222, 548223, 548224, 548241, 5483061, 5483615, 5483625, 548525, 548539, A61K 3140, C07D20709
Patent
active
055763430
ABSTRACT:
An anticoagulant agent which comprises, as an active ingredient, an aromatic amidine derivative represented by the following general formula (1) or a salt thereof: ##STR1## wherein the group represented by ##STR2## is a group selected from indolyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, naphthyl, tetrahydronaphthyl and indanyl; X is a single bond, an oxygen atom, a sulfur atom or a carbonyl group; and Y is a saturated or unsaturated 5- or 6-membered heterocyclic moiety or cyclic hydrocarbon moiety optionally having a substituent group, an amino group optionally having a substituent group or an aminoalkyl group optionally having a substituent group.
The inventive compound has a high anticoagulant capacity based on its excellent FXa inhibition activity.
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Tidwell et al, "Strategies for Anticoagulation with Synthetic Protease Inhibitors-Xa Inhibitors Versus Thrombin Inhibitors", Thrombosis Research, 19:339-349 (1980).
Hauptmann et al, ACTA Biologica Et Medica Germanica, 35:635-644 (1976).
Markwardt, "Zur Wirkung Von Aromatischen Bisamidinen Auf Blutgerinnungs-Und Fibrinolysevorg ange".
Inamura Kazue
Kanaya Naoaki
Nagahara Takayasu
Yokoyama Yukio
Dahlen Garth M.
Daiichi Pharmaceutical Co. Ltd.
Ivy C. Warren
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