Aromatic amides of heterocyclic compounds and therapeutic compos

Details Aromatic amides of heterocyclic compounds and therapeutic compos Aromatic amides of heterocyclic compounds and therapeutic compos

1975-03-17

1979-02-06

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

544335, 542469, 546197, 546224, 546194, 546213, 546187, 546190, 546233, 546234, C07D21158, A61K 31445

Patent

active

041384920

ABSTRACT:
The invention relates to aromatic amides N-substituted by heterocyclic groups. More particularly, the invention relates to substituted benzoic acid amides of 1-arylalkylamino or aminoalkyl-N-heterocyclic rings and to pharmaceutical compositions thereof, which have the ability to antagonize the effects of dopamine or dopaminergic agents of endogenous or exogenous origin and which may be used for the treatment of nausea and vomiting resulting from gastrointestinal disorders, congestive heart failure, post operative conditions, etc., other gastrointestinal disorders such as dyspepsia, flatulence, bile regurgitations, hiatus hernia, peptic ulcer, reflux aerophagitis, gastritis, duodenitis, and cholethiasis, and a variety of conditions affecting the central nervous system such as acute and chronic psychoses, maniacal psychosis, schizophrenias, serious disturbances of behavior and non-melancholic depressive state and migraine.

REFERENCES:
patent: 3342826 (1967-09-01), Miller et al.
patent: 3862139 (1975-01-01), Podesua et al.
patent: 3879401 (1975-04-01), Archibald et al.
patent: 3910931 (1975-10-01), Cavalla et al.
patent: 3963745 (1976-06-01), Cale et al.
Harper et al., J. Med. Chem. 7: 729-732, (1964).
Newberry et al., C.A. 77: 151,956g, (1972).
Lamotte-Barrillon et al., C.A. 76: 67,982j, (1972).
Chemical Abstracts, vol. 8, (1975) 114199r, abstracting Ger. Offen. 2,316,644 (1973).

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