Aromatic acid intermediates

Details Aromatic acid intermediates Aromatic acid intermediates

1991-09-03

1993-10-05

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562429, 540222, C07C31117

Patent

active

052507254

ABSTRACT:
The present invention relates to novel cephalosporin derivatives with improved pharmacokinetics, corresponding to the formula: ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3 represent a hydrogen atom, or R.sub.1 and R.sub.2 represent a hydrogen atom or a methyl group and R.sub.3 represents a carboxyl group, or ##STR2## form a cyclobutyl group and R.sub.3 represents a carboxyl group; and A and B are different and occupy the meta and para positions of the benzene ring, one representing a hydroxyl group and the other being selected from the groups ##STR3## and --NH--SO.sub.2 --Alk--NH.sub.2 in which Alk denotes a C.sub.2 -C.sub.4 lower alkylene group and also to the pharmaceutically acceptable salts and esters of the said derivatives.
It further relates to a process for the preparation of such cephalosporins and to pharmaceutical compositions in which they are present.

REFERENCES:
patent: 4344862 (1982-08-01), Widder et al.
patent: 4950661 (1990-08-01), Olliero et al.
patent: 4960929 (1990-10-01), Bapenfuhs

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