Aromatase inhibitors

Details Aromatase inhibitors Aromatase inhibitors

1984-06-18

1989-01-31

Henderson, Christopher

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514359, 514381, A61K 3141, A61K 3144

Patent

active

048015946

ABSTRACT:
This invention provides azole derivatives, their pharmaceutical formulations, and their use in methods of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals.

REFERENCES:
patent: 4094881 (1978-06-01), Berges
patent: 4098894 (1978-07-01), Buchal et al.
patent: 4227004 (1980-10-01), Wildonger
Chem. Abst., 71, 61296p (1969).
Chemical Abstracts 89:24368q (1978).
Fisher, et al., "5-Aroyltetrazoles," J. Org. Chem., 24, 1650 (1959).
Burgess, et al., "Synthesis . . . of . . . Azafulvenes," J. Org. Chem., 39(7), 940 (1974).
Adelstein, "Antiarrhythmic Agents . . . ", J. Med. Chem., 16(4), 309 (1973).
Balieu, et al., "Tetrazole Analogues . . . ", Acta Chemica Scandinavica, 27, 1233 (1973).
Chemical Abstracts 89:179927v (1978).
Balieu, et al., "Tetrazole Analogues . . . ", Acta Chemica Scandinavica, 26, 2951 (1972).
Zaugg et al., "Reactions of some ester alkaloids . . . ," J. Org. Chem., 23, 847 (1958).

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