Aromatase-inhibiting composition containing azole derivative

Details Aromatase-inhibiting composition containing azole derivative Aromatase-inhibiting composition containing azole derivative

1994-10-21

1998-08-04

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514383, 514396, 514397, A61K 21415, A61K 3141

Patent

active

057894329

ABSTRACT:
The disclosure describes a pharmaceutical composition comprising an aromatase-inhibiting effective amount of a compound selected from the group consisting of compounds of the formula (I): ##STR1## including their stereoisomers and salts thereof, wherein R.sup.1 is halogen or phenyl; m is 0, 1, 2 or 3; k and n each are independently 0, 1 or 2; R.sup.2 and R.sup.3 each are independently H or OH; R.sup.6 and R.sup.7 each are independently H or C.sub.1-4 alkyl; R.sup.8 and R.sup.9 each are H or R.sup.8 and R.sup.9 form --C(R.sup.4) (R.sup.5)--C(R.sup.11) (R.sup.12)-- bond wherein R.sup.4, R.sup.5, R.sup.11 and R.sup.12 each are independently H or C.sub.1-4 alkyl; Y is N or CH; and R.sup.10 is H or halogen, or R.sup.10 combines with R.sup.2 to form --O-- bond, with proviso that if R.sup.8 and R.sup.9 form --C(R.sup.4) (R.sup.5)--C(R.sup.11) (R.sup.2)-- bond, R.sup.3, R.sup.6 and R.sup.7 each are H, and k and n each are 1, then R.sup.2 and R.sup.10 form --O-- bond, and a pharmaceutically acceptable carrier or diluent.

REFERENCES:
patent: 4902702 (1990-02-01), Enari et al.
patent: 4962278 (1990-10-01), Enari et al.
patent: 5010206 (1991-04-01), Enari et al.
patent: 5286737 (1994-02-01), Kato et al.
Database WPI, Week 9336, Derwent Publications Ltd., London, GB; AN 93-278159 & JP A 5 194 119 (Hokko Chemical Ind.) 3 Aug. 1993 Abstract.
Database WPI, Week 8813, Derwent Publications Ltd., London, GB; AN 88-089208 & JP A 63 041 479 (Kureha Chemical Ind.) 22 Feb. 1988 Abstract.
A Kato et al., Chem. Pahrm. Bull., 43. (12), pp. 2152-2158 (1995).
Angela M. H. Brodie et al., Breast Cancer Research and Treatment, 30, pp. 1-6 (1994).
Angela M. H. Brodie et al., Pharmac. Ther., 60, pp. 501-515 (1993).
T. Yamamoto et al., J. Steroid Biochem., 36, 6, pp. 517-521 (1990).
M. Jawed Igbal et al., Clinical Science, 65, pp. 71-75 (1983).
M. DiMattina et al., Fertility and Sterility, 49, (1), pp. 62-65 (1988).
Paul A. J. Janssen et al., J. Med. Chem., 32, (10), pp. 2231-2239 (1989).

Affiliated with

Also associated with

Rating

Aromatase-inhibiting composition containing azole derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aromatase-inhibiting composition containing azole derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aromatase-inhibiting composition containing azole derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1177599