Aromatase-inhibiting composition containing azole derivative

Details Aromatase-inhibiting composition containing azole derivative Aromatase-inhibiting composition containing azole derivative

1996-03-28

1998-03-10

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514397, A61K 3141, A61K 31415

Patent

active

057261962

ABSTRACT:
The disclosure describes a pharmaceutical composition comprising an aromatase-inhibiting effective amount of a compound selected from the group consisting of compounds of the formula (I): ##STR1## including their stereoisomers and salts thereof, wherein R.sup.1 is halogen or phenyl; m is 0, 1, 2 or 3; k and n each are independently 0, 1 or 2; R.sup.2 and R.sup.3 each are independently H or OH; R.sup.6 and R.sup.7 each are independently H or C.sub.1-4 alkyl; R.sup.8 and R.sup.9 each are H or R.sup.8 and R.sup.9 form --C(R.sup.4) (R.sup.5)--C(R.sup.11) (R12)-- bond wherein R.sup.4, R.sup.5, R.sup.11 and R.sup.12 each are independently H or C.sub.1-4 alkyl; Y is N or CH; and R.sup.10 is H or halogen, or R.sup.10 combines with R.sup.2 to form --O-- bond, with proviso that if R.sup.8 and R.sup.9 form --C (R.sup.4) (R.sup.5)--C(R.sup.11) (R.sup.12)-- bond R.sup.3, R.sup.6 and R.sup.7 each are H, and k and n each are 1, then R.sup.2 and R.sup.10 form --O-- bond, and a pharmaceutically acceptable carrier or diluent.

REFERENCES:
patent: 4902702 (1990-02-01), Enari et al.
patent: 4962278 (1990-10-01), Enari et al.
patent: 5010206 (1991-04-01), Enari et al.
patent: 5286737 (1994-02-01), Kato et al.
Database WPI, Week 9336, Derwent Publications Ltd., London, GB; AN 93-278159 & JP A 5 194 119 (Hokko Chemical Ind.) 3 Aug. 1993 Abstract.
Database WPI, Week 8813, Derwent Publications Ltd., London, GB; AN 88-089208 & JP A 63 041 476 (Kureha Chemical Ind.) 22 Feb. 1988 Abstract.

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