Aromastase inhibiting .alpha.,.alpha.-diarylimidazole-4(5)-propi

Details Aromastase inhibiting .alpha.,.alpha.-diarylimidazole-4(5)-propi Aromastase inhibiting .alpha.,.alpha.-diarylimidazole-4(5)-propi

1984-06-18

1986-08-12

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514341, 514396, 546278, 548335, 548342, A61K 31415, A61K 3144, C07D23364, C07D40106

Patent

active

046056610

ABSTRACT:
This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain imidazole derivatives. Pharmaceutical formulations of the imidazole derivatives and certain imidazoles are also provided.

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patent: 4398942 (1983-08-01), Ikari et al.
Siiteri et al., Handbook of Physiology-Endocrinology II, Part 1, pp. 615-629.
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Harris, Expl. Cell Biol., 53, pp. 1-8 (1985).
Brodie et al., Endocrinology, 100, pp. 1684-1695, (1977).
Coombes et al., Lancet, pp. 1237-1239 (Dec. 1, 1984).
Santen et al., Ann. Int. Med., 96, pp. 94-101 (1982).
Barone et al., J. Clin. Endocrin. and Metabol., 49(5), pp. 672-676 (1979).
Berkowitz et al., Amer. J. Epid., 121(2), pp 238-245 (1985).
Tseng et al., J. Clin. Endocrin. and Metabol., 55(5), pp. 1029-1031 (1982).

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