Aristeromycin analogues of 4',5'-didehydro-5'-fluoro-adenosine a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 45, 514 81, 536 2714, 536 274, 536 292, 544262, A61K 3170, A61K 31675, C07D48700

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active

055211623

ABSTRACT:
This invention relates to certain aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.

REFERENCES:
patent: 3472837 (1969-10-01), Verheyden et al.
patent: 3825541 (1974-07-01), Vince et al.
patent: 3910885 (1975-10-01), Moffatt et al.
patent: 4321376 (1982-03-01), Otani et al.
patent: 4386093 (1983-05-01), Chiang et al.
patent: 4387228 (1983-06-01), Montgomery et al.
patent: 4423218 (1983-12-01), Otani et al.
patent: 4728736 (1988-03-01), Shealy et al.
patent: 4816575 (1989-03-01), Fukukawa et al.
patent: 4916224 (1990-04-01), Vince et al.
patent: 4954504 (1990-09-01), Chen et al.
patent: 4968690 (1990-11-01), Marquez et al.
Ferrier, "4',5'-Unsaturated Cyclic Compounds," Advances in Carbohydrate Chemistry and Biochemistry, 24, 250-251 (1969).
Bennett et al., "Differences in the Metabolism and Metabolic Effects of the Carbocyclic Adenosine Analogs, Neplanocin A and Aristeromycin," Mol. Pharmacol., 29, 383-390 (1986).
DeClercq, "S-Adenosylhomocysteine Hydrolase Inhibitors as Broad Spectrum Antiviral Agents," Biochem. Pharmacology, 36, 2567-2575 (1987).
Brimacombe, "The Synthesis of Rare Sugars," Angewandte Chemie. Intl. Ed., 8(6), 401-468 (1969).
Cook et al., "Nucleoside 4',5'-Enol Acetates. Synthesis and Chemistry of a Unique Uridine O.sup.2, 4'-Anhydronucleoside," J. Am. Chem. Soc., 101, 1554-1564 (1979).
Jenkins et al., "4'-Substituted Nucleosides. 2. Synthesis of the Nucleoside Antibiotic Nucleocidin," J. Am. Chem. Soc., 98(11), 3346-3357 (1976).
Richards et al., "Synthesis of 4'-Methoxyadenosine and Related Compounds," Carbohydrate Research, 100, 315-329 (1982).
Verheyden et al., "Synthesis of Certain 4'-Substituted Nucleosides," Ann. N.Y. Acad. Sci., 225, 151-165 (1975).
Aarbakke et al., "Induction of HL-60 Cell Differentiation by 3-Deaza(.+-.)-Aristeromycin, an Inhibitor of S-Adenosylhomocysteine Hydrolase," Cancer Res., 46, 5469-5472 (1986).
Montgomery et al., "Carbocyclic Analogue of 3-Deazaadenosine: A Novel Antiviral Agent Using S-Adenosylhomocystgeine Hydrolase as a Pharmacological Target," J. Med. Chem., 25, 626-629 (1982).
DeClercq et al., "Broad-Spectrum Antiviral Activity of the Carbocyclic Analog of 3-Deazaadenosine," Antiviral Res., 3, 17-24 (1983).
Baker et al, "5'-Substituted-5'-Deoxy Nucleosides," Tetrahedron, 30, 2939-2942 (1974).
Craig et al., "Synthesis of 9-[5-(Alkylthio)-5-deoxy-.beta.-D-erythro-pent-4-enofuranosyl)adenines as Potential Inhibitors of Transmethylation," J. Org. Chem. 51, 1258-1264 (1986).
Palmer et al., "The Mechanism of Action of S-Adenosylhomocyteinase," J. Biol. Chem., 254(4), 1217-1225 (1979).

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