Aripiprazole complex formulation and method

Details Aripiprazole complex formulation and method Aripiprazole complex formulation and method

2006-06-14

2009-06-23

Maier, Leigh C (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S254070, C514S574000

Reexamination Certificate

active

07550445

ABSTRACT:
An aripiprazole formulation is provided which includes the antipsychotic agent aripiprazole in the form of an inclusion complex in a β-cyclodextrin, preferably, sulfobutyl ether β-cyclodextrin (SBECD), which in the form of an injectable produces reversible generally minimal to mild irritation at the intramuscular injection site. A method for minimizing or reducing irritation caused by aripiprazole at an intramuscular injection site and a method for treating schizophrenia employing the above formulation are also provided.

REFERENCES:
patent: 4983586 (1991-01-01), Bodor
patent: 5006528 (1991-04-01), Oshiro et al.
patent: 5134127 (1992-07-01), Stella et al.
patent: 5376645 (1994-12-01), Stella et al.
patent: 5646131 (1997-07-01), Badwan et al.
patent: 5773029 (1998-06-01), Chiesi et al.
patent: 5855916 (1999-01-01), Chiesi et al.
patent: 5904929 (1999-05-01), Uekama et al.
patent: 6232304 (2001-05-01), Kim et al.
patent: 6407079 (2002-06-01), Müller et al.
patent: 6632803 (2003-10-01), Harding
patent: 6713461 (2004-03-01), Billotte
patent: 6977257 (2005-12-01), Parab et al.
patent: 7115587 (2006-10-01), Nerurkar et al.
patent: 2004/0146562 (2004-07-01), Shah
patent: 1 145 711 (2001-10-01), None
patent: 9-301867 (1997-11-01), None
patent: WO 03/026659 (2003-04-01), None
patent: WO 03/064393 (2003-08-01), None
Rajewski, R.A. et al., “Pharmaceutical Applications of Cyclodextrins. 2. In Vivo Drug Delivery”, Journal of Pharmaceutical Sciences, vol. 85, No. 11, 1996, pp. 1142-1169.
Szejtli, J., “Cyclodextrins in Drug Formulations: Part I”, Pharmaceutical Technology International, vol. 3, No. 2, pp. 15-22, (1991).
Szejtli, J. “Cyclodextrins in Drug Formulations: Part II”, Pharmaceutical Technology International, vol. 3, No. 3, pp. 16-24, (1991).

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