Arglabin compounds and therapeutic uses thereof

Details Arglabin compounds and therapeutic uses thereof Arglabin compounds and therapeutic uses thereof

1998-10-07

2000-02-01

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549299, A61K 3134, C07D30793

Patent

active

06020365&

ABSTRACT:
The invention provides various derivatives of arglabin, a sesquiterpene lactone isolated from Artemisia glabella. These compounds are effective for suppressing tumor growth in mammals. A method of suppressing tumor growth in humans is also described.

REFERENCES:
patent: 5663196 (1997-09-01), Sari et al.
S.M. Adekenov, A. D. Kagarlitskii Khimiya Seskviterpenovykh Laktonov (The Chemistry of Sesquiterpene Lactones) Alma-Ata, Gylym, 188 pages, (1990).
Adekenov, S.M., Mukhametshanov, M. N., Kupriyanov, A. N., Kagarlitskii, A.D., Khim. Prir. Seodin, 5, 655-56 (1982).
S. M. Adekenov, K.M. Turdybekov, K.A. Aituganov, S. V. Lindeman, Yu. T. Struchkov, and S. N. Shaltakov, "1.beta., 10.alpha.-Dihydroxyarglabin--A New Sesquiterpene Lactone from Artemisia glabella," Chemistry of Natural Compounds, vol. 29, No. 6, 1993, pp. 735-739.
"The Merck Index," Merck & Co., 1983, pp. 329, 394, 408, 599, 1427 and 1428.
Adekenov et al., "Reactions at the double bond and epoxy group of arglabin," 547, 314: 548, 737, pp. 33-42, 1991.
Blanco et al., "A novel activity for a group of sesquiterpene lactones: inhibition of aromatase," FEBS Letters vol. 409, No. 3, (1997) pp. 396-400.
Giordano et al., "The Gastric Cytoprotective Effect of Several Sesquiterpene Lactones," Journal of Natural Products, vol. 53, No. 4, pp. 803-809, Jul.-Aug. 1990.
Guardia et al., "Mucus Synthesis and Sulfhydryl Groups in cytoprotection mediated by Dehydroleucodine, A Sesquiterpene Lactone," Journal of Natural Products, vol. 57, No. 4. pp. 507-509, Apr. 1994.
Barbacid, M., Ann. Rev. Biochem., vol. 56:, pp. 779-827 (1987).
Gibbs et al., Proc. Natl. Acad. Sci. USA, vol. 81, pp. 5704-5708 (Sep. 1984).
Jung et al., Molecular and Cellular Biol., vol. 14, No. 6, pp. 3707-3718 (Jun. 1994).
Marom et al., J. Biol. Chem., vol. 270, No. 38, pp. 22263-22270 (1995).
Prendergast et al., Mol. Cell. Biol., vol. 14, No. 6, pp. 4193-4202 (Jun. 1994).
Shears et al., Biochem. J., vol. 219, pp. 375-382 (1984).
Vogt et al., J. Biol. Chem., vol. 270 No. 2, pp. 660-664 (1995).
Adekenov et al., Fitoterapia, vol. LXVI, No. 2, pp. 142-146 (1995).
Bottex-Gauthier et al., Biotechnology Therapeutics, 4 (1&2), pp. 77-98 (1993).
Epstein et al., Proc. Natl. Acad. Sci. USA, vol. 88, pp. 9668-9670 (Nov. 1991).

Affiliated with

Also associated with

Rating

Arglabin compounds and therapeutic uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Arglabin compounds and therapeutic uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arglabin compounds and therapeutic uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-937950