Arginyl tRNA synthetase from staphyloccus aureus

Details Arginyl tRNA synthetase from staphyloccus aureus Arginyl tRNA synthetase from staphyloccus aureus

1997-12-23

1999-10-12

Hobbs, Lisa

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 435440, 5303871, C12N 900, C12N 1500, C12Q 168, C07K 1600

Patent

active

059654163

ABSTRACT:
The invention provides tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

REFERENCES:
patent: 5561054 (1996-10-01), Kron et al.
Kron, et al., "An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase", FEBS Letters, 374 pp. 122-124 (1995).
Chalker, et al., "Analysis and toxic overexpression in Escherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase", Gene, 141, pp. 103-108 (1994).
Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc. Natl. Acad. Sci. USA, 85, pp. 3604-3607 (1988).
Kazura, et al., "Differential Recognition of a Protective Filarial Antigen by Antibodies from Humans with Bancroftian Filariasis", J. Clin. Invest., 77, pp. 1985-1992 (1986).

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