Arginine silicate complex and use thereof

Details Arginine silicate complex and use thereof Arginine silicate complex and use thereof

1997-02-12

1998-01-13

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 63, 514565, 536121, 562561, 556 9, A61K 3170, A61K 31695, A61K 31195, C07D48722

Patent

active

057079706

ABSTRACT:
An arginine silicate-containing complex and its use in the prevention and treatment of atherosclerosis and as a dietary supplement. The arginine silicate complex is synthesized by combining arginine, potassium silicate and inositol. The complex is administered orally three times per day in an amount ranging from about 250 mg to about 2,500 mg as a preventative or therapeutic agent.

REFERENCES:
patent: 3337403 (1967-08-01), Zentner
patent: 4297349 (1981-10-01), Barcza
patent: 4385052 (1983-05-01), Zackheim et al.
patent: 5250569 (1993-10-01), Godfrey
patent: 5622980 (1997-04-01), Caldwell et al.
T.J. Bassler, (1978) "Hard water, food fibre, and silicon", British Medical Journal 1:919.
A. Calver, et al., (1992) "Effect of local intra-arterial N.sup.G -monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal", Journal of Hypertension 10:1025-1031.
E.M. Carlisle, (1972) "Silicon: An Essential Element for the Chick", Science 178:619-621.
E.M. Carlisle, (1976) "In vivo Requirement for Silicon in Articular Cartilage and Connective Tissue Formation in the Chick", J. Nutr. 106:478-484.
P.Y. Chen, et al., (1991) "L-Arginine Abrogates Salt-sensitive Hypertension in Dahl/Rapp Rats", J. Clin. Invest. 88:1559-1567.
P. Clarkson, et al., (1996) "Oral L-Arginine Improves Endothelium-dependent Dilation in Hypercholesterolemic Young Adults", J. Clin. Invest. 97(8):1989-1994.
A.W. Clowes, et al., (1977) "Suppression by heparin of smooth muscle cell proliferation in injured arteries" Nature 265:625-626.
J.P. Cooke, et al., (1994) "Is NO an Endogenous Antiatherogenic Molecule" Arteriosclerosis and Thrombosis 14(5):653-655.
M.A. Creager, et al., (1992) "L-Arginine Improves Endothelium-dependent Vasodilation in Hypercholesterolemic Humans" J. Clin. Invest. 90:1248-1253.
H. Drexler, et al., (1991) "Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine", Lancet 338:1546-1550.
E.R. Edelman, et al., (1990) "Effect of controlled adventitial heparin delivery on smooth muscle cell proliferation following endothelial injury", Proc. Natl. Acad. Sci. USA 87:3773-3777.
L.R. Garson, et al., (1971) "Organosilicon Entities as Prophylactic and Therapeutic Agents", Journal of Pharmaceutical Sciences 60(8):1113-1127.
J.R. Guyton, et al., (1980) "Inhibition of Rat Arterial Smooth Muscle Cell Proliferation by Heparin . . . ", Circ. Res. 46:625-634.
P. Laurent, et al.,( 1995) "Dietary L-Arginine Attenuates Blood Pressure in Mineralocorticoid-Salt Hypertensive Rats", Clin. and Exper. Hypertension 17(7):1009-1024.
J. Loeper, et al., (1979) "The Antiatheromatous Action of Silicon", Atherosclerosis 33:397-408.
J. Loeper, et al., (1978) "The Physiological Role of the Silicon and its Antiatheromatous Action", in Biochemistry of Silicon and Related Problems, Bendz, G. et al. Eds., Plenum Press, NY 281-296.
S. Moncada, et al., (1993) "The L-Arginine-Nitric Oxide Pathway", The New England Journal of Medicine 329(27):2002-2012.
R.M. Parr, (1980) "Silicon, Wine, and the Heart", Lancet p. 1087.
G.M. Rubanyi, M.D., Ph.D., (1991) "Endothelium-Derived Vasoactive Factors in Health and Disease", in Cardiovascular Significance of Endothelium-Derived Vasoactive Factors, Rubanyi, G.M., ed., Futura Publishing Company, Inc., NY xi-xix.
K. Schwarz, et al., (1972) "Growth-promoting Effects of Silicon in Rats", Nature 239:333-334.
K. Schwarz, (1977) "Silicon, Fibre, and Atherosclerosis", Lancet 454-457.
K. Schwarz, et al., (1977) "Inverse Relation of Silicon in Drinking Water and Atherosclerosis in Finland", Lancet 538-539.
K. Schwarz, (1978) "Significance and Functions of Silicon in Warm-Blooded Animals", in Biochemistry of Silicon and Related Problems, Bendz, G. et al. Eds., Plenum Press, NY 207-230.

Affiliated with

Also associated with

Rating

Arginine silicate complex and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Arginine silicate complex and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arginine silicate complex and use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-326276