Arginine keto-amide enzyme inhibitors

Details Arginine keto-amide enzyme inhibitors Arginine keto-amide enzyme inhibitors

1995-06-05

1999-02-09

Weber, Jon P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514822, 530331, A61K 3800, A61K 3806, C07K 5097

Patent

active

058694544

ABSTRACT:
The present invention is directed to novel arginine alpha-keto-amide derivatives, their pharmaceutically acceptable salts and compositions thereof which are useful as antithrombotic agents in mammals and also the use of these compounds as antithrombotic agents. Also, described are methods of using these inhibitors as inhibitors of coagulation proteases and as therapeutic agents for disease states characterized by abnormal thrombus formation and/or disorders of the blood coagulation process. Further described herein are compounds useful as intermediates in the preparation of these compounds.

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