Arginine derivatives and pharmaceutically acceptable acid additi

Details Arginine derivatives and pharmaceutically acceptable acid additi Arginine derivatives and pharmaceutically acceptable acid additi

1987-06-19

1988-08-16

Warden, Robert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546205, 546206, C07D40512

Patent

active

047646187

ABSTRACT:
Novel arginine derivatives represented by the general formula ##STR1## wherein R.sup.1 stands for a naphthalenesulfonyl, a naphthalenecarbonyl, a 1,2,3,4-tetrahydronaphthalenesulfonyl, a 1,2,3,4-tetrahydronaphthalenecarbonyl, a dioxa b-6,7-naphthalenesulfonyl, a dioxa b-6,7-naphthalenecarbonyl, a 1,2,3,4-tetrahydro-8-quinolinesulfonyl, a 1,2,3,4-tetrahydro-8-quinolinecarbonyl, a dibenzofuransulfonyl, a dibenzofurancarbonyl, a fluorenesulfonyl, a fluorenecarbonyl, a dibenzothiophenesulfonyl or a dibenzothiophene, and R.sup.2 stands for a piperidino or a piperazino are disclosed. These arginine derivatives and their pharmaceutically acceptable salts have trypsin-inhibiting activity and useful as a pancreatitis remedy.

REFERENCES:
patent: 4066773 (1977-01-01), Okamoto
patent: 4073914 (1978-02-01), Kikumoto
Nesheim, "Biochemistry" 18(6), pp. 996-1003 (1979).
Kikumoto-II, "J. Med. Chem." (23), pp. 1293-1299 (1980).

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