Arginine and lysine salts of acid cephalosporins

Details Arginine and lysine salts of acid cephalosporins Arginine and lysine salts of acid cephalosporins

1973-06-19

1976-10-05

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50160

Patent

active

039844030

ABSTRACT:
Arginine or lysine salt of acid cephalosporins can be administered parenterally, e.g., by intramuscular injection, with no substantial pain. Preferred acid cephalosporin salts are l-arginine or lysine salts of N-[7-(.alpha.-sulfophenylacetamido)ceph-3-em-3-ylmethyl]-pyridinium-4-carb oxylate, N-[7-(.alpha.-sulfophenylacetamido)-ceph-3-em-3-ylmethyl]-(4'-carbamoyl)py ridinium 4-carboxylate, 7-cyanoacetamido-cephalosporanic acid, 7-(2'-thienylacetamido)-3-[6"-(3"-methylpyridazinyl)thiomethyl]-ceph-3-em- 4-carboxylic acid 2"-oxide, 7-tetrazolylacetamido-3-[5'-(2'-methylthiadiazolyl)thiomethyl]-ceph-3-em-4 -carboxylic acid and 7-(2'-thienylacetamido)-cephalosporanic acid.

REFERENCES:
patent: 3280118 (1966-10-01), Fardley et al.
patent: 3488730 (1970-01-01), Stephens
patent: 3676434 (1972-07-01), Massey
patent: 3708478 (1973-01-01), Chapman et al.

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