Arginase II

Details Arginase II Arginase II

1997-08-20

1999-06-15

Low, Christopher S.F.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435195, 536 232, 935 14, 935 22, 935 62, 935 70, 514 2, 514 12, C12N 978

Patent

active

059121599

ABSTRACT:
The invention relates to Arginase II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

REFERENCES:
Cederbaum et al.; Hyperargininemia with Arginase Deficiency; Pediat. Res. 13:827-833 (1979).
Cederbaum et al.; Hyperargininemia; The Journal of Pediatrics, vol. 90, No. 4, pp. 569-573 (1977).
Dizikes et al; Isolation of Human Liver Arginase cDNA and Demonstration of Nonhomology Between the Two Human Arginase Genes; Biochemical & Biophysical Research Communications; 141:1; 53-59 (1986).
Grody et al.; Arginase Deficiency Manifesting Delayed Clinical Sequelae and Induction of a Kidney Arginase Isozyme; Human Genetics 91:1-5 (1993).
Grody et al.; Differential Expression of the Two Human Arginase Genes in Hyperargininemia; J. Clin. Invest. vol. 83, pp. 602-609 (1989).
Michels et al.; Arginase Deficiency in Multiple Tissues in Argininemia; Clinical Genetics 13:61-67 (1978).
Spector et al,; Immunologic Studies of Arginase in Tissues of Normal Human Adult and Arginase-Deficient Patients; Pediatric Research; vol. 17, No. 12; pp. 941-944 (1983).
Posters: Gene Structure and Function; The American Journal of Human Genetics; vol. 55, No. 3; A139 (1994).
Gotoh et al.; Molecular Cloning of cDNA for Nonhepatic Mitochondrial Arginase (Arginase II) and Comparison of Its Induction with Nitric Oxide Synthase . . .; FEBS Letters 395; pp. 119-122 (1996).
Jenkinson et al.; Comparative Properties of Arginase; Comp. Biochem, Physiol . . .; vol. 114B, No. 1; pp. 107-132 (1996).
Vockley et al.; Cloning and Characterization of the Human Type II Arginase Gene; Genomics 38; pp. 118-123 (1996).
Wissman, P.B. et al.; "Gene transfer of liver arginase into different subcellular compartments", Am. J. Hum. Genet, 1994, 55(3) 55(3);A139 (Abstact #800).
Baker, et al. 1982 in "The Study of Biology", Fourth edition, Addision-Wesley Publ. Co., Reading, MA (p. 9).
Entrez(ver.7.0) released Oct.T08457, issn 1065-707X, National Center for Biotechnology Information.
Adams et al. 1993, Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library. Nature Genetics 4: 373-380.
EST# 688451.
EST# 157442.

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