ARG.sup.7 -ARG.sup.8 -vasopressin antagonists

Details ARG.sup.7 -ARG.sup.8 -vasopressin antagonists ARG.sup.7 -ARG.sup.8 -vasopressin antagonists

1986-06-23

1988-01-05

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514807, 530315, H61K 3734, C07K 716

Patent

active

047177152

ABSTRACT:
Vasopressin antagonists which have a dipeptide side chain comprised of two basic amino acids demonstrate potent V.sub.1 and V.sub.2 -antagonist activity. A species of the invention, which is prepared by conventional peptide sequencing, is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylene propionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-arginine-8-arginine-9-desglycine]- vasopressin.

REFERENCES:
patent: 4469679 (1984-09-01), Huffman et al.
patent: 4481193 (1984-11-01), Ali et al.
patent: 4481194 (1984-11-01), Ali et al.
M. Manning et al., Nature, 308 652 (1984).

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