Arg-arg-arg-vasopressin antagonists

Details Arg-arg-arg-vasopressin antagonists Arg-arg-arg-vasopressin antagonists

1986-09-30

1988-02-09

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514807, 530315, C07K 716, A61K 3734

Patent

active

047242299

ABSTRACT:
Vasopressin antagonists which have a tripeptide side chain comprised of three basic amino acids, such as arginine, lysine or ornithine, demonstrate potent V.sub.1 and V.sub.2 -antagonist activity. A species of the invention, which is prepared by conventional peptide sequencing, is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-arginine-8-arginine-9-arginine]-va sopression.

REFERENCES:
patent: 4469679 (1984-09-01), Huffman et al.
patent: 4481193 (1984-11-01), Ali et al.
patent: 4481194 (1984-11-01), Ali et al.
patent: 4649130 (1987-03-01), Manning et al.
Chem. Abstracts 88337y, Moore et al.
Chem Abstracts 117716, Moore et al.
M. Manning et al. Peptides, Struce and Function Proc. 9th Ann Peptide Sym. Deber. C. M. et al. eds. Pierce Chemical Co. Rockford Illinois 1985 pp. 599-602.
M. Manning et al., Nature, 308, 652 (1984).

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