Areno [e]indols, preparation method and application as intermedi

Details Areno [e]indols, preparation method and application as intermedi Areno [e]indols, preparation method and application as intermedi

1996-07-03

1997-05-20

Haley, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548429, C07D48702, C07D20956

Patent

active

056313845

ABSTRACT:
The compounds (I) are useful as intermediates in the synthesis of hexahydroareno(e)cyclopropa(c)indol-4-ones with antitumoral activity.

REFERENCES:
Paul Carter, Steven Fitzjohn, Serge Halazy, and Philip Magnus, "Studies on the Synthesis of the Antitumor Agent CC-1065 Synthesis of PDE I and PDE II, Inhibitors of Cyclic Adenosine-3',5'-monophosphate Phosphodiesterase using the 3,3'-Bipyrrole Strategy", J. Am. Chem. Soc. (1987), 109, 2711-2717.
Frank B. Mallory and Clelia W. Mallory, "Photocyclization of Stilbenes and Related Molecules", Organic Reactions, vol. 30, (1984) pp. 266-313.
Viresh H. Rawal, Robert J. Jones and Michael P. Cava, "Palladium Mediated Dehydrogenation in the Photochemical Cyclization of Heterocyclic Analogs of Stilbene", Tetrahedron Letters, vol. 26, No. 20, (1985) pp. 2423-2426.
Viresh H. Rawal, Robert J. Jones and Michael P. Cava, "Photocyclization Strategy for the Synthesis of Antitumor Agent CC-1065: Synthesis of Dideoxy PDE-I and PDE-II. Synthesis of Thiophene and Furan Analogues of Dideoxy PDE-I and PDE-II", J. Org. Chem., 1987, 52, 19-28, (1987).
Kevin J. Drost and Michael P. Cava, "A Photochemically Based Synthesis of the Benzannelated Analogue of the CC-1065 A Unit", J. Org. Chem., (1991), 56, 2240-2244.
Viresh H. Rawal, Robert J. Jones, and Michael P. Cava, "Review of Synthetic Studies Toward CC-1065, PDE-I, and PDE-II.sup.+ ", Heterocycles, vol. 25, (1987).

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