Arene-transition metal linkers for solid phase synthesis

Details Arene-transition metal linkers for solid phase synthesis Arene-transition metal linkers for solid phase synthesis

1997-05-22

2000-05-02

Nazario-Gonzalez, Porfirio

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

556 20, 556 46, 556 47, 556 58, 556 59, 556136, 556140, 556141, 556142, 787 2, 787 3, C07F 1100, C07F 1500

Patent

active

060574658

ABSTRACT:
Compositions and methods for the solid phase synthesis of organic compounds are provided. The compositions are solid supports having an attached traceless linker precursor and are represented by the formula: ##STR1## In this formula, S.sup.0 is a solid support; B is a connecting group; M is a transition metal, for example ruthenium, chromium, iron, molybdenum and manganese; each L is independently a transition metal ligand; the letter n represents an integer of from 1 to 4, such that M has a sufficient number of ligands to fill the available valences; and X.sup.- represents an anion which is typically a non-nucleophilic anion.

REFERENCES:
patent: 5624711 (1997-04-01), Sundberg et al.
Chenera et al. (1995), "Protodetachable arylsilane polymer linkages for use in solid phase organic synthesis," J. Am. Chem. Soc. 117:11999-12000.
Donaldson (1997), "Preparation and reactivity of acyclic (pentadienyl)iron(1+) cations: applications to organic synthesis," Aldrichimica Acta 30(1):17-24.
Farrall et al. (1976), "Bromination and lithiation: two important steps in the functionalization of polystyrene resins," J. Org. Chem. 41(24):3877-3882.
Gordeev et al (1996), "Approaches to combinatorial synthesis of heterocycles: a solid-phase synthesis of 1,4-dihydropyridines," J. Org Chem. 61:924-928.
Han et al. (1996), "Silicon directed ipso-substitution of polymer bound arylsilanes: preparation of biaryls via the suzuki cross-coupling reaction," Tetrahedron Letters 37(16): 2703-2706.
Holmes et al. (1995), "Reagents for combinatorial organic synthesis: development of a new o-nitrobenzyl photolabile linker for solid phase synthesis," J. Org. Chem. 60:2318-2319.
Murphy et al. (1995), "Combinatorial organic synthesis of highly functionalized pyrrolidines: identification of a potent angiotensis converting enzyme inhibitor from a mercaptoacyl proline library," J. Am. Chem. Soc. 117:7029-7030.
Pearson (1989), "Recent developments in the synthetic applications of organoiron and organomolybdenum chemistry," in Advances in Metal-Organic Chemistry, vol. 1, pp. 1-49.
Plunkett et al. (1995), "A silicon-based linker for traceless solid-phase synthesis," J. Org. Chem. 60:6006-6007.
Ruhland et al. (1996), "Solid-supported combinatorial synthesis of structurally diverse .beta.-lactams," J. Am. Chem. Soc. 118:253-254.
Toda et al. (1996), "1:1 and 2:1 inclusion complexes of (R,R)-(-)-trans-2,3-bis(hydroxydiphenyl-methy)-1,4-dioxaspiro[4,4]nonane with N-allylfuran-2-carboxanilide which upon irradiation in the solid state give (-) and (+)-photocyclization products, respectively," J. Org. Chem. 61:6490-6491.

Affiliated with

Also associated with

Rating

Arene-transition metal linkers for solid phase synthesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Arene-transition metal linkers for solid phase synthesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arene-transition metal linkers for solid phase synthesis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1595069