Aralkyl substituted piperazine compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S254110, C544S377000, C544S400000

Reexamination Certificate

active

06852723

ABSTRACT:
Novel compounds of the general formula:and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.

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Pepine et al., “A Controlled Trial with a Novel Anti-Ischemic Agent, Ranolazine, in Chronic Stable Angina Pectoris That is Responsive to Coventional Antianginal Agents”,American Journal of Cardiology, vol. 84, pp. 46-50 (1999).

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