Aralkoxy and aryloxyalkoxy kojic acid derivatives

Details Aralkoxy and aryloxyalkoxy kojic acid derivatives Aralkoxy and aryloxyalkoxy kojic acid derivatives

1984-07-11

1987-02-17

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31500

Patent

active

046440712

ABSTRACT:
This invention relates to substituted aralkoxy and aryloxyalkoxy kojic acid derivatives, which are useful as leukotriene D.sub.4 (LTD.sub.4) inhibitors and therefore useful in the treatment of allergies, inflammatory conditions, and coronary vasoconstriction.

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M. Griffin et al., "Effects of Leukotriene D on the Airways in Asthma", N. Engl. J. Med., 308, 436-439 (1983).
R. A. Lewis & K. F. Austen, "Mediation of Local Homeostasis and Inflammation by Leukotrienes and Other Mast Cell-Dependent Compounds", Nature, 293, 103-108 (1981).
F. Michelassi et al., "Leukotriene D.sub.4 : A Potent Coronary Artery Vasoconstrictor Associated with Impaired Ventricular Contraction," Science, 217, 841-843 (1982).
J. A. Burke et al., "Leukotrienes C.sub.4, D.sub.4 and E.sub.4 : Effects on Human and Guinea-Pig Cardiac Preparations in Vitro," J. Pharmacol. and Exp. Therap., 221, 235-241 (1982).
R. A. Appleton et al., "Antagonists of Slow Reacting Substance of Anaphylaxis, Synthesis of a Series of Chromone-2-Carboxylic Acids", J. Med. Chem., 20, 371-379 (1977).

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