Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1991-12-20
1993-03-02
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 86, 514 88, 514 91, 514 94, 514 95, 514 99, 514107, 544243, 546 22, 548112, 548119, 549 6, 549218, 562 13, A61K 3166, A61K 3167, A61K 31665, A61K 31675, C07F 906, C07F 902, C07F 928
Patent
active
051909308
ABSTRACT:
Araliphatylaminoalkanediphosphonic acids of formula ##STR1## wherein R.sub.1 is an aromatically substituted aliphatic radical, R.sub.2 is hydrogen or a monovalent aliphatic radical and alk is a divalent aliphatic radical, and their salts, exhibit a pronounced regulatory action on the calcium metabolism and can be used as medicaments for the treatment of diseases that are attributable to calcium metabolsim disorders. They are prepared, for example, by reacting a compound of formula ##STR2## wherein X.sub.3 is carboxy and R.sub.0 is a radical R.sub.2, with phosphorous acid and phosphorus trichloride and hydrolysing the primary product.
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Ciba-Geigy Corporation
Fishman Irving M.
Kaiser Karen G.
Tsang Cecilia
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