Arachidonic acid releasing phospholipase A2 enzyme and methods o

Details Arachidonic acid releasing phospholipase A2 enzyme and methods o Arachidonic acid releasing phospholipase A2 enzyme and methods o

1990-02-28

1997-04-22

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435198, 536 232, C12Q 144, C12N 1555, C12N 920

Patent

active

056228325

ABSTRACT:
The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.

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