Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1996-05-22
1998-05-19
MacMillan, Keith
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
A61K 3123
Patent
active
057537020
ABSTRACT:
The present invention provides methods and products for inhibiting neutrophil adhesion and neutrophil aggregation. The invention includes a method for treating a subject to inhibit neutrophil adhesion and neutrophil aggregation by administering 16-hydroxyeicosatetraenoic acid (16-HETE) to the subject. 16-HETE is an arachidonic acid metabolite. The invention also includes a pharmaceutical preparation of 16-HETE.
REFERENCES:
patent: 5256538 (1993-10-01), Aiken et al.
Chemical Abstracts AN 1995:138771, Takada et al.
Chemical Abstracts AN 1990:493392, Falck et al.
Chemical Abstracts AN 1994:474474, Knickle et al.
Falck, J.R. et al., The Journal of Biological Chemistry, vol. 265 (18):10244-10249 (1990).
Heckmann, B. et al. . Tetrahadron Letters, vol. 37(9):1425-1428 (1996).
Bednar, M.M. et al.. Abstract from meeting held in Florence, Italy (Jun. 1994).
Ying Zhu et al.. Hypertension, vol. 25 (4),Part 2:854-859 (Apr. 1995).
Gross, C.E. et al. . Neurological Res. , vol. 16:465-470 (Dec. 1994).
Lesch, M.E. et al. . Agents and Actions, vol. 34:25-27 (1991).
Lee, T.H. et al. . The New England Journal of Medicine, vol. 312(19):1217-1224 (5/9/85).
Hill, E. et al. . Biological Mass Spectrometry, vol. 21:249-253 (1992).
Watanabe, Masako et al. , Br. J. Pharmacol, 102:239-245 (1991).
Laethem, R.M. et al. , the Journal of Biological Chemistry, vol. 268(17):12912-12918 (1993).
Balazy, M., The Journal of Biological Chemistry, vol. 266(35):23561-23567 (1991).
Bednar, M.M. et al., Journal of Thrombosis and Thrombolysis:1:179-185 (1995).
Springer, T.A. , Annu. Rev. Cell Biol. , 6:359-402 (1990).
Kraemer, R. et al. , American Journal of Pathology, vol. 128(3):446-454 (1987).
Hatzelmann A. et al. , Euro. J. Biochem. 173:445-452 (1988).
Balazy Michael
Bednar Martin M.
Falck John R.
Gross Cordell E.
MacMillan Keith
University of Vermont
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