Arachidonic acid analogs

Details Arachidonic acid analogs Arachidonic acid analogs

1984-08-06

1986-07-08

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

556449, 568448, 568700, 562506, C07F 708, C07F 718

Patent

active

045994390

ABSTRACT:
Analogs of arachidonic acid are provided having the structure ##STR1## wherein R is CH.sub.2 OH or CO.sub.2 H and m is 1 or 2. These compounds are useful as inhibitors of leukotriene and prostaglandin biosynthesis and as such are useful an antiallergy and antiinflammatory agents.

REFERENCES:
patent: 4304934 (1981-12-01), Bartels-Keith et al.
"Irreversible Inhibition of Prostaglandin and Leukotriene Biosynthesis from Arachidonic Acid by 11,12-Dehydro- and 5,6-Dehydroarachidonic Acids, Respectively", E. J. Corey and John E. Munroe, J. Am. Chem. Soc. 1982, 104, 1752-1754.
"Irreversible Inhibition of the Leukotriene Pathway by 4,5-Dehydroarachidonic Acid," E. J. Corey, et al., Tetrahydro Letters, vol. 24, No. 3, pp. 265-268, 1983.
"Mechanism of the Irreversible Deactivation of Arachidonate 5-Lipoxygenase by 5,6-Dehydroarachidonate", E. J. Corey et al., J. Am. Chem. Soc. 1984, 106, 1501-1503.

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