Arabinofuranosyl N.sup.4 -aminoacyl cytosine containing compound

Details Arabinofuranosyl N.sup.4 -aminoacyl cytosine containing compound Arabinofuranosyl N.sup.4 -aminoacyl cytosine containing compound

1974-08-30

1976-08-17

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, 424180, 536 23, C07C10352, C07H 1906, C07H 1908

Patent

active

039753670

ABSTRACT:
Certain new 1-(3',5'-O-Variable-.beta.-D-arabinofuranosyl)-N.sup.4 -.alpha.-aminoacylcytosines, for example, 1-(5'-O-palmitoyl-.beta.-D-arabinofuranosyl)-N.sup.4 -[N.sup..alpha.-[N-(tert-butoxycarbonyl)glycyl]-L-arginyl]cytosine hydrochloride, have been found active against neoplastic cells, viruses, and as immunosuppressants. The 3'-O-, or 5'-O-, variability includes the hydrogen atom and acyl groups. The N.sup.4 -.alpha.-aminoacyl group comprises .alpha.-amino acids, N-protected .alpha.-amino acids, and similar peptidyl sequences of .alpha.-amino acids. Acid addition salts are an embodiment of the invention.

REFERENCES:
patent: 3089869 (1963-05-01), Mauvernay
patent: 3155647 (1964-11-01), Dutcher et al.
patent: 3309359 (1967-03-01), Duschinsky et al.
patent: 3755295 (1973-08-01), Verheyden et al.

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