Aqueous suspensions of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphen

Details Aqueous suspensions of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphen Aqueous suspensions of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphen

1976-03-05

1977-07-05

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260243C, A61K 31545

Patent

active

040340899

ABSTRACT:
The antibacterial agent 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5- ylthiomethyl)-3-cephem-4-carboxylic acid, which is a zwitterion, is both purified and converted to a form highly suitable for use in aqueous suspensions by converting it to the crystalline 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5- ylthiomethyl)-3-cephem-4-carboxylic acid 1,2-propylene glycolate, said propylene glycolate containing 1.0 - 1.6 moles of 1,2-propylene glycol per mole of cephalosporin zwitterion.

REFERENCES:
patent: 3867380 (1975-02-01), Dunn et al.
The Merck Index Eighth Edition pp. 876-877(1968).

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