Aqueous suspension of loteprednol etabonate

Details Aqueous suspension of loteprednol etabonate Aqueous suspension of loteprednol etabonate

1998-03-05

1999-06-29

Azpuru, Carlos A.

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Ophthalmic preparation

424434, 424435, A61K 3174

Patent

active

059165502

ABSTRACT:
The conventional aqueous suspension of loteprednol etabonate is not easily amenable to production pH control and entails a pH depression on long-term storage, thus irritating the eye or the nasal mucosa on instillation.
When a C2-7 aliphatic amino acid is added to an aqueous suspension of loteprednol etabonate for topical ophthalmic use, the suspension does not undergo pH depression even on prolonged storage, with the result that no irritable response is elicited in the eye or nasal mucosa.

REFERENCES:
patent: 5540930 (1996-07-01), Guy et al.

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