Aqueous spray-coating process

Coating processes – Fraud or tamper detecting

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424471, 424482, 427 12, A61K 932

Patent

active

050472585

ABSTRACT:
A process for spray-coating tablets and the like utilizing only an acrylate enteric polymer and plasticizer in water is disclosed. The process can be practiced on a commercial scale and requires no antiadherent in the coating formulation. The process comprises providing inlet air having a dew point below about 10.degree. C. and a temperature between 35.degree. and 60.degree. C.

REFERENCES:
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patent: 4606909 (1986-08-01), Bechgaard et al.
patent: 4775536 (1988-10-01), Patell
patent: 4800087 (1989-01-01), Mehta
patent: 4816264 (1989-03-01), Phillips et al.
Eudragit L 30 D brochure, Rohm Pharma GmbH; undated, pp. 1-7.
Dechesne et al. "Study of the Application Conditions for Enterically Soluble and Gastroresistant Coatings Eudragit.RTM. L30D." J. Pharm. Belg. 37, 273-282 (1982) (original and translation thereof).
Lehmann "Herstellung und Verwendung von Latices aus redespergierbaren Pulvern anionischer Acrylharze."Acta Pharm. Tech. 31,96-105 (1985).
Lehmann "Chemistry and Application Properties of Polymethacrylate Coating Systems" in Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, J. W. McGinity ed. Marcel Dekker 1989; pp. 153-245; 191-192.
Mehta "Processing and Equipment Considerations for Aqueous Coatings" in Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, J. W. McGinity ed.; Marcel Dekker 1989 pp. 256-302.
Ebey "A Thermodynamic Model for Aqueous Film-Coating"Pharmaceutical Technology 11, 40-50 (1987).
Reiland et al. "Aqueous Film-Coating Vaporization Efficiency", Drug Development and Industrial Pharmacy 9, 945-958 (1983).
Chowhan "Scale-up of the Aqueous Film Coating Process" in Proceedings of the Pharm. Tech. Conference '86, Sep. 16-18, 1986 Aster Publishing, Springfield, OR; pp. 264-279.

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