Aqueous spectinomycin borate solutions

Details Aqueous spectinomycin borate solutions Aqueous spectinomycin borate solutions

1995-03-01

1996-09-17

Seidleck, James J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

424659, 549361, A01N 4332

Patent

active

055568793

ABSTRACT:
Aqueous pharmaceutical compositions containing up to about 40% spectinomycin, prepared by the reaction of the ketone hydrate of spectinomycin with boric acid to form the boron compound, and with a base such as sodium hydroxide to form the stable salt of the compound.

REFERENCES:
"The Chemistry of Actinospectacin", Wiley, P. F., Argoudelis, A. D., Hoeksma, H. J., J. Am. Chem. Soc. 85, 2652, (1963).
"Stereochemistry and Absolute Configuration of the Antibiotic Spectinomycin", Cochran, T. G., Abraham, D. J., J.C.S. Chem. Comm. 495, (1972).

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