Aqueous solution of a tissue plasminogen activator dissolved the

Details Aqueous solution of a tissue plasminogen activator dissolved the Aqueous solution of a tissue plasminogen activator dissolved the

1985-02-26

1986-02-04

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

260112R, 424 85, 424 95, 424103, 424105, 424113, 435 68, 4351723, 435188, 435212, 435215, 435216, 435217, 435240, C12N 948, A61K 3704, A61K 3548, A61K 3754

Patent

active

045685444

ABSTRACT:
An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration which comprises an aqueous medium and, dissolved therein, a high purity tissue plasminogen activator and at least one dissolution aid selected from the group consisting of lysine, ornithine and salts thereof, and a method for increasing a solubility of a high purity tissue plasminogen activator in an aqueous medium comprising adding said at least one dissolution aid to an aqueous solution of a high purity tissue plasminogen activator. The present aqueous solution contains a high purity tissue plasminogen activator dissolved therein at an increased concentration and the activity of the tissue plasminogen activator can be maintained during handling and storage of the aqueous solution. Therefore, not only can be easily and efficiently performed the treatment of a tissue plasminogen activator in each purification step but also can be stored safely, stably an aqueous tissue plasminogen activator solution as a final product.

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