Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-30
1997-04-29
Clardy, S. Mark
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514443, 514444, 514448, 514777, 514950, 424488, A61K 3140, A61K 31445, A61K 4740
Patent
active
056249403
ABSTRACT:
The present invention provides aqueous inclusion complexes of certain known benzothiophene compounds, particularly Raloxifene, and water soluble cyclodextrins. Also provided are pharmaceutical compositions of such inclusion complexes, and methods of using these complexes for inhibiting bone loss and reducing serum cholesterol in mammals.
REFERENCES:
patent: 4133814 (1979-01-01), Jones et al.
patent: 4380635 (1983-04-01), Peters
patent: 4418068 (1983-11-01), Jones
patent: 4727064 (1988-02-01), Pitha
patent: 4764604 (1988-08-01), M uller
patent: 5015648 (1991-05-01), Humphrey et al.
patent: 5019563 (1991-05-01), Hunter et al.
patent: 5043326 (1991-08-01), Stadler n ee Szoke et al.
patent: 5089482 (1992-02-01), Hermans et al.
patent: 5101065 (1992-03-01), Skuballa et al.
patent: 5134127 (1992-07-01), Stella et al.
patent: 5229370 (1993-07-01), Ammeraal
patent: 5393763 (1995-02-01), Black et al.
patent: 5464845 (1995-11-01), Black et al.
Draper, et al., "Effects of Raloxifene (LY139481 HC1) on Biochemical Markers of Bone and Lipid Metabolism in Healthy Postmenopausal Women", Hong Kong, Fourth Int'l. Symp. on Osteoporosis, Mar. 29, 1993.
Bryant, et al., "Protection from Bone Loss and Lowering of Serum Cholesterol in the Absence of uterine Stimulation in Overiectomized Rats", Am. Soc. Bone & Min., Tampa, Sep. 18-22, 1993.
Inclusion Compounds, 3(11):333-389, Atwood, J.L., et al., (eds.), Academic Press (1984).
Controlled Drug Delivery, 5:125-148, Pitha, J., et al., Bruck S.D., (ed), CRC Press (1983).
Draper et al, "Effects of raloxifene . . . on biochemical markers of bone . . . " 4th Internat'l Symp. on Osteoporosis. Mar. 29, 1993.
Szejtli, "Industrial Applications of Cyclodextrins" Ch. 11 of Inclusion Compounds v. 3, Atwood et al, ed. Acad. Pr., 1984. pp. 331-389.
Bryant Henry U.
Cullinan George J.
Francis Paul C.
Magee David E.
Sweetana Stephanie A.
Boone David E.
Clardy S. Mark
Eli Lilly and Company
Strode Janelle D.
LandOfFree
Aqueous solution inclusion complexes of benzothiophene compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aqueous solution inclusion complexes of benzothiophene compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aqueous solution inclusion complexes of benzothiophene compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-706009