Aqueous protein solutions stable to denaturation

Details Aqueous protein solutions stable to denaturation Aqueous protein solutions stable to denaturation

1987-12-22

1989-12-05

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

424 855, 424 856, 424 857, 424 941, 424 9461, 424 9664, 514 2, 514 3, 514 12, 514 13, 514 15, A61K 3900, A61K 3512, A61K 3700, A61K 3726

Patent

active

048851647

ABSTRACT:
What are disclosed are a method for preventing the denaturation of proteins such as insulin in aqueous solution at interfaces by the addition to the solution of a surface-active substance comprising a chain of alternating weakly hydrophobic and weakly hydrophilic zones, protein solutions containing such a surface-active substance, methods of purifying proteins contained in such solutions, and methods of treating surfaces with such a surface-active material to prevent the denaturation of proteins thereon.

REFERENCES:
patent: 4153689 (1979-05-01), Hirai et al.
patent: 4179337 (1979-12-01), Davis et al.
patent: 4637834 (1987-01-01), Thurow

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