Aqueous protein solutions stable to denaturation

Details Aqueous protein solutions stable to denaturation Aqueous protein solutions stable to denaturation

1983-12-21

1988-11-08

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 424 943, A61K 3700, A61K 3726

Patent

active

047834412

ABSTRACT:
What are disclosed are a method for preventing the denaturation of proteins such as insulin in aqueous solution at interfaces by the addition to the solution of a surface-active substance comprising a chain of alternating weakly hydrophobic and weakly hydropholic zones, protein solutions containing such a surface-active substance, methods of purifying proteins contained in such solutions, and methods of treating surfaces with such a surface-active material to prevent the denaturation of proteins thereon.

REFERENCES:
patent: 4073886 (1973-01-01), Kehm
patent: 4129560 (1978-12-01), Zoltobrocki
patent: 4153689 (1979-05-01), Hirai et al.
patent: 4179337 (1979-12-01), Davis et al.
Chemical Abstracts 81 (26) 176134h & 176135j (1974).
Chemical Abstracts (80) (1974) 22796t.
Cecil et al., Biochem. J. (1970) 117, 147-156.
Schobert et al., Biochim. et Biophys. Acta (1978) 541, 270-277.
"Insulin, etc.", Proc. 2nd Intnl. Insulin Symposium, 9/4-7/79, de Gruyter, Berlin (1980) pp. 215-221.
The Merck Index, Merck & Co., Rahway, N.J. (1976) p. 1261.
Advances in Protein Chemistry, vol. 23, Academic Press, New York (1968) pp. 121-122, 211-217.
A Physico-Chemical Approach to the Denaturation of Proteins, Joly, Academic Press, New York (1965) pp. vii-ix, 30-36.

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