Aqueous prolonged release formulation

Details Aqueous prolonged release formulation Aqueous prolonged release formulation

1996-12-13

2000-11-21

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514805, 530399, A61K 3800

Patent

active

061503304

ABSTRACT:
Prolonged parenteral release into the circulatory system of a cow of a bioactive growth hormone releasing factor at desirably effective levels can be achieved using novel compositions in which the growth hormone releasing factor is present in an aqueous liquid at a dose of at least about 50 mg and at a concentration of at least about 20 mg/ml. Preferably, the growth hormone releasing factor is present in an aqueous liquid at a dose of about 200 mg and at a concentration of about 180 mg/ml. The aqueous bovine somatotropin formulation provides for the sustained release of bovine somatotropin into the circulatory system of the animal for greater than seven (7) days.

REFERENCES:
patent: 4977140 (1990-12-01), Ferguson
patent: 5013713 (1991-05-01), Mitchell
patent: 5352662 (1994-10-01), Brooks
patent: 5756458 (1998-05-01), Kubiak et al.
Tucker et al., J. Dairy Sci., 78:1489-1497, (1995).
Dahl et al., J. Dairy Sci., 77:2518-2525, (1994).
Pitt, C.G.; "The controlled parental delivery of polypeptides and proteins"; International Journal of Pharmaceutics, vol. 59, pp. 173-196 (1990).
Mariette, Be atrice; "Release of the GRF29NH.sub.2 analog of human GRF44NH.sub.2 from a PLA/GA matrix"; Journal of Controlled Release, vol. 24, pp. 237-246 (1993).
Carmona, P.; "Structural study of human growth hormone-releasing factor fragment (1-29) by vibrational spectroscopy"; Spectrochimica Acta, vol. 51A, No. 5, pp. 929-938 (1995).

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