Aqueous process for the preparation of 5-methyl-n-(aryl)-1,2,4-t

Details Aqueous process for the preparation of 5-methyl-n-(aryl)-1,2,4-t Aqueous process for the preparation of 5-methyl-n-(aryl)-1,2,4-t

1989-11-06

1991-01-29

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

5482638, C07D48704

Patent

active

049888129

ABSTRACT:
5-Methyl-N-(aryl)-1,2,4-triazolo[1,5-a]-pyrimidine-2-sulfonamides are prepared by the cyclization of N -(3-(((aryl)amino)sulfonyl)-1H-1,2,4-triazol-5-yl)amines with 4-methoxy-3-butene-2-one or its synthetic equivalents in the presence of an aqueous base. By controlling the pH of the condensation between 8.5 and 10.5, by-product formation can be substantially reduced.

REFERENCES:
patent: 2444606 (1948-07-01), Heimbach et al.
patent: 4617303 (1986-10-01), Eicken et al.
patent: 4650892 (1987-03-01), Kleschick et al.
patent: 4734123 (1988-03-01), Monte
patent: 4755212 (1988-07-01), Kleschick et al.
patent: 4854964 (1989-08-01), Jelich
patent: 4886883 (1989-12-01), Keschick et al.

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