Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-08-28
2007-08-28
Tsang, Cecilia J. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
10518924
ABSTRACT:
The present invention relates to an aqueous pharmaceutical preparation of oligopeptides comprising an oligopeptide of the formula I, cyclo-(n-Arg-nGly-nAsp-nD-nE), and a partially etherified β-cyclodextrin having a water solubility of greater than 1.8 mg/ml of water, and to the preparation of the aqueous pharmaceutical preparation.
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patent: WO9111200 (1991-08-01), None
patent: WO 0062793 (2000-10-01), None
Kamm, W. et al: “Evaluation of Absorption Enhancement for a Potent Cyclopeptidic.Alpha..Nu..Beta.3-Antagonist in a Human Intestinal Cell Line (CACO-2)” European Journal of Pharmaceutical Sciences (2000), 10(3), 205-214, Seite 206, Linke Spalte, Letzter Absatz; Seite 208, Linke Spalte, Absatz 3; Seite 213, Linke Spalte, Absatz 2-Absatz 3.
Johnson, M.D. et al., “Solubilization of tripeptide HIV protease inhibitor using a combination of ionization and complexation with chemically modified cyclodextrin,” Journal of Pharm. Sci., Aug. 1994, pp. 1142-1146 (abstract).
Lindenblatt Hiltrud
Zobel Hans-Peter
Bradley Christina Marchetti
Merck Patent GmbH
Millen White Zelano & Branigan P.C.
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