Aqueous preparation and method of preparation thereof

Details Aqueous preparation and method of preparation thereof Aqueous preparation and method of preparation thereof

1987-02-03

1989-04-18

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

A61K 3112

Patent

active

048228230

ABSTRACT:
This invention relates to an aqueous preparation comprising a compound (A) represented by the formula: ##STR1## and at least one of cyclodextrins selected from .alpha.-cyclodextrin and dimethyl-.beta.-cyclodextrin; and a method of preparation thereof.
According to the aqueous preparation of this invention, coexistence with at least one medicament selected from .alpha.-cyclodextrin and dimethyl-.beta.-cyclodextrin allows to enhance the solubility to water of compound (A) essential in this invention to such a concentration that makes an expected curative effect available and to inpart a desired stability to it. As a consequence, the aforesaid compound (A) can be utilized as a medicament for an aqueous preparation having anti-allergy action.

REFERENCES:
"The Merck Index", Tenth Edition, pp. 389 and 390, No. 2712, 1983.
Szejtli, Journal of Inclusion Phenomena, vol. 1, pp. 135 to 150, 1983.
Chem. Abstr., 101, No. 8, 307, 60129n, 1984 (corresponds to AT2).
Chem. Abstr., 100, No. 21, 596, 174440s, 1984.
Patent Abstracts of Japan, 6, No. 90, May 27, 1982.
Patent Abstracts of Japan, 9, No. 228, Sep. 13, 1985.
Patent Abstracts of Japan, 5, No. 184, Nov. 21, 1981.
Patent Abstracts of Japan, 8, No. 134, Jun. 21, 1984 (corresponds to AR1).

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