Aqueous pharmaceutical preparations of G-CSF with a long shelf l

Details Aqueous pharmaceutical preparations of G-CSF with a long shelf l Aqueous pharmaceutical preparations of G-CSF with a long shelf l

1997-05-15

1999-07-06

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 21, A61K 3817

Patent

active

059197579

ABSTRACT:
Aqueous pharmaceutical preparations of G-CSF are disclosed that are stable on storage and a buffer selected from the group consisting of a salt of citrate, maleate, a combination of phosphate and citrate, and arginine; and at least one surfactant.

REFERENCES:
patent: 4992419 (1991-02-01), Woog et al.
patent: 5104651 (1992-04-01), Boone et al.
M. Oh-eda et al.; "Olinked Sugar Chain of Human Granulocyte Colony-stimulating Factor Protects It against Polymerization and Denaturation Allowing It to Retain Its Biological Activity"; The Journal of Biological Chemistry, vol. 265, No. 20, Jul. 15, 1990, pp. 11432-11435.
The Merck Index, 12.sup.th ed., Pub. Merck & Co., Inc. Rahway, NJ, U.S.A. (1996). pp. 627 and 773.
Neupogen.RTM. product package insert, Amgen, Nov. 25, 1992.

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