Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Aftertreated solid synthetic organic polymer
Reexamination Certificate
2006-03-13
2009-11-03
Weddington, Kevin (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Aftertreated solid synthetic organic polymer
C514S058000, C514S311000, C514S312000
Reexamination Certificate
active
07612115
ABSTRACT:
The present invention has an object to provide an antibacterial aqueous pharmaceutical composition and an aqueous pharmaceutical composition which have a sufficiently low gelation temperature even when new quinolone antibacterial agents such as ofloxacin as the active ingredient and can be retained at the administration site for a long time by virtue of rapid viscosity increase after administration in spite of their being liquid at administration and thereby attain high availability of pharmaceutical agent.The present invention relates to an antibacterial aqueous pharmaceutical compositionwhich comprises: 2.8 to 4 w/v % of methylcellulose, the 2 w/v % aqueous solution of which has a viscosity of 12 mPa·s or below at 20° C.; 1.5 to 2.3 w/v % of citric acid; 2 to 4 w/v % of polyethylene glycol; and 0.1 to 0.5 w/v % of ofloxacin.
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Kirita Masanobu
Suzuki Hidekazu
Takeuchi Masanobu
Wada Takahiro
Chapman and Cutler LLP
Wakamoto Pharmaceutical Co., Ltd.
Weddington Kevin
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